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NICHD DASH Migration

DASH is currently being migrated to the NIH BRICS platform. This migration will enhance NICHD data stewardship and increase DASH functionality and efficiency to meet NICHD researcher and staff needs. Please check back soon for updates. If questions arise, please contact SupportDASH@mail.nih.gov.

Adaptive Antiretroviral Therapy Adherence Interventions for Youth Living with HIV through Text Messaging and Cell Phone Support Embedded within the Sequential Multiple Assignment Randomized Trial (SMART) Design (ATN 144)

Submission Date: August 21, 2025
 

Study Description: This project tested an adaptive adherence intervention to improve self-management and achieve/maintain viral load suppression while understanding the context for wide-scale implementation in an effectiveness-implementation Type 1 Hybrid trial. Primary aims: 1) Compare cell phone support (CPS) vs. text messaging (SMS) for youth living with HIV (YLH) not virally suppressed; 2) Understand the benefits of incentives for non-responders (NRsp), identify how to taper interventions for responders (Rsp), and describe potential moderators of treatment effect; 3) Study barriers and facilitators to wide-spread implementation and cost-effectiveness of treatment sequences. We hypothesized that youth randomized to CPS will have significantly greater viral load suppression (primary outcome) and self-reported medication adherence (secondary outcome) than those in the SMS group.

Investigating Donor Human Milk Composition Globally to Develop Effective Strategies for the Nutritional Care of Preterm Infants (Global DHM Study)

Submission Date: August 15, 2025
 

Study Description: Donor human milk (DHM) is the recommended food for small vulnerable infants when mother's milk is not available, due to evidence that it protects against NEC. While DHM use is increasing around the world, there are significant knowledge gaps about DHM that imped clinical care. This project addresses DHM knowledge gaps through a study conducted with eight geographically diverse milk bank partners in high, middle, and low-income settings. We examine and compare a broad range of nutrients in milk from 600 approved milk bank donors around the world to create comprehensive, geographically diverse nutrient profiles for DHM (Aim 1). Milk bank-level practices for pooling donors are evaluated using simulation to identify effective strategies that can be used by milk banks to create more consistent nutrient profiles in DHM (Aim 2). Finally, we evaluate whether currently available commercial fortifiers meet nutrient recommendations when used with DHM and identify nutrients to enhance in the development of a DHM-specific fortifiers (Aim 3).

Adolescent Master Protocol for Participants 18 Years of Age and Older - Lite, PH400 (AMP Up Lite)

Submission Date: August 11, 2025
 

Study Description: This study investigated the long-term outcomes of perinatal HIV (PHIV) and its treatment on young adults with perinatally acquired HIV (YAPHIV). The primary objectives were to: 1) identify infectious and non-infectious complications of HIV disease and toxicities resulting from long-term ART; 2) define the impact of HIV infection and ART on the long-term clinical outcomes in YAPHIV; and 3) define the impact of perinatal HIV infection, its concomitant risk factors, and ART on long-term mental and behavioral health outcomes. Data collection included clinical assessments, online surveys, interviews, specimen collection, and medical chart abstraction, designed to achieve the primary objectives, as well as the domain specific study aims. Results can be used to help design intervention strategies to improve the quality of life of young adults with perinatal HIV.

Adolescent Master Protocol for Participants 18 Years of Age and Older, PH300 (AMP Up)

Submission Date: July 8, 2025
 

Study Description: This study investigated the long-term outcomes of perinatal HIV (PHIV) and its treatment on young adults with perinatally acquired HIV (YAPHIV). Young adults living with perinatal HIV exposure without perinatally acquired HIV (YAPHEU) were also enrolled. The primary objectives were to: 1) identify infectious and non-infectious complications of HIV disease and toxicities resulting from long-term ART; 2) define the impact of HIV infection and ART on the long-term clinical outcomes in YAPHIV; and 3) define the impact of perinatal HIV infection, its concomitant risk factors, and ART on long-term neurocognitive and behavioral health outcomes. Data collection included clinical assessments, online surveys, interviews, laboratory testing, specimen collection, and medical chart abstraction, designed to achieve the primary objectives and domain specific study aims. Results can be used to help design intervention strategies to improve the quality of life of young adults with perinatal HIV.